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MindMap Gallery Immunology

Immunology

This is a mind map that contains information about the immunology.

Edited at 2020-10-12 05:40:00

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Immunology

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Outline

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MMkbtXpa

Immunology

signalling

cytokines

antiinflammatory

IL10

TGF beta

IL2

inflammatory

TNF

targets

IL 1

IL 6

targets

IL 12

IFN Gamma

IL 8

IL15

IFN type 1

Chemokines

Lymph node localisation

CCL19 &amp; CCL21

CXCL5

recruitment into the infection site

CCL2

CCL11

CXCL8

CCL5

CCL3

homing of naive T and B cells

Lipid mediators

inflammatory

Prostaglandins (PGI2)

Leukotrienes

Platelet activating factor

Antiinflammatory

Glucocorticoids

Cortisol

Vasoactive amines

Histamine

co stimulation

B cell to T cell

CD40

Antigen presenting cell to T cell

Inhibitory

CTLR4

Activating

CD28

Intracellular signalling

initiation

general principles

1) Receptor Activation

2) Tyrosine Kinase (TK) Activation

TK Structure

3) Transcription factors

BCR, TCR and TLR

TCR complex

Mechanism

BCR complex

Mechanism

regulation of TCR / BCR signaling

TLR Mechanism

localisation

Adhesion

integrin

LFA1

Also help cell to cell adhesionfor MHC sampling

selectin

Eselectin

Pselectin

Lselectin

immune tissue

Primary

Bone Marrow

fetal liver

Thymus

Seconday

Lymph nodes

Spleen

Peyers patch

Peripheral tissue

mucosal immune tissues

Adaptive

B cells

B cell receptor

Co receptors

Ig alpha

Ig beta

Bcell development

Bone marrow

Ig gene rearrangement V(D)Jrecombination

Antibody production

IgM

IgG

IgA

IgE

T cells

T cell development

1. Bonemarrow

2. Thymus

3. Activation and proliferation inperipheral tissues

CD4+ Th cells

T cell subsets

Treg

Natural FOXP3+ Treg

Inducible iTreg

CD4+

TH17

TH1

TH2

T(FH)

CD8+

Cytotoxic T cells

gamma delta T cells

T cell receptor

Co receptors

CD3

Zeta

Medical Approach

vaccines

Features

Example: peptide vaccines

Adjuvants

Example: Hep B

Transplant

Tissue matching

Immunosuppression

Azathioprine

Corticosteriods

CyclosporinA

Sirolimus

Evolution of the Immune system

Deutrostromes

Jawless vertebrates

Innate and acquired immunity

Jawed vertebrates

Innate and novel acquired immunity

Protosomes

Innate immunity

Innate

Cellular

Granulocyte

Neutrophils

Basophils

Eosinophils

histamine &amp; leukotriene

Mast cells

Monocytes

Macrophage

Dendritic

innatelike lymphocytes

Natural Killer NK cells

perforin

B1 cells

epithelial gamma:delta cells

NK T cells

Non Cellular

Lysozyme

defensins

Transferrin

opsinisaton and complementactivating proteins

Pentraxins

Collectins

Ficollins

Complement

Natural Antibodies

Pathogens

Parasites

Trypanosomai Brucei

Schitosomiasis spp.

fungal infection

Aspergillus Fumigatus

Cryptococcus neoformans

Candida Albicans

Immune responses againstfungal infections

Viruses

Innate immune response

IFN type I

NK cells

Adaptive immune response

Antibodies

Cytotoxic T cells

Retroviruses

Human T lymphotropic VIrus (HTLV) 1

Human Immunodeficiency Virus (HIV)

Disorders

Hypersensitivity

Type I: IgE mediated

Anaphylaxis

Allergy

Atopy

Allergic Asthma

Type II: IgM and IgG mediated

Type III: immune complex mediated

type IV: T cell mediated

multiple sclerosis

type I diabetes

contact sensitivity

Cancer

Tumour Antigens

Vaccines against oncogenic DNA Viruses

Immune responses against cancer

NK cells

Macrophages

CD8+ T cells

Autoimmunity