(Insufficient renal perfusion) functional failure organic failure

(respiratory membrane damage)

Coronary artery function reduced blood flow

Acidosis or hyperkalemia has a depressive effect on myocardium

myocardial inhibitory factor

intramyocardial DIC

Cytotoxicity inhibits myocardial function

There is spasm of blood all over the body, and the Yang force in front of the capillaries increases significantly. Blood flow slows down, blood flow is limited Fortunately, the circuit is closed, the movement and movement are short-circuited and misfired, and tissue perfusion is reduced.

Sympathetic-adrenomedullary system excitement

Vasoconstrictor substances

Muscular venules and venules contract, and the hepatic blood reservoir contracts, rapidly and briefly increasing blood return to the heart. volume, called “autotransfusion”

The front resistance of capillaries is greater than the rear resistance (arteries are greater than veins), and tissue fluid flows back into the blood, which is called "autoinfusion"

blood redistribution

Increased myocardial contractility and increased peripheral resistance

Pale face, cold limbs, cold sweat, thin pulse, decreased pulse pressure, irritability Note: blood pressure changes, can be normal or reduced

Spasm of arterioles and posterior arterioles is reduced, venules dilate, and blood flows into the capillary network, Increased resistance at the venous end (posterior resistance is greater than anterior resistance), microcirculatory blood stasis

Ischemia and hypoxia cause acidosis, which leads to reduced vascular responsiveness to catecholamines

Ischemia and hypoxia lead to increased production of local blood-expanding substances

Due to the effect of endotoxin (intestinal bacteria entering the bloodstream), LPS can cause vasodilation through multiple pathways

Blood rheology changes (related to white blood cells)

Blood progressively decreases and various manifestations increase to varying degrees

Hemoconcentration, increased blood viscosity, and blood in a hypercoagulable state

Acidosis

The role of septic shock toxins

The role of septic shock toxins and traumatic shock tissue factor entering the blood