Easily fatigued, sensitive to cold, weight gain, drowsiness, depression, etc. Physical examination revealed apathetic expression, pale complexion, dry and cool skin, edema, hoarseness, and sparse hair.

Fatigue, myotonia, cramps and cold pain that are aggravated by cold, muscle atrophy or hypertrophy

Bradycardia, decreased cardiac output, small pulse compression, and coronary heart disease are easy to occur when accompanied by hypertension, but angina is less likely to occur. Pericardial effusion and heart failure can occur. ECG shows low voltage

Slow speech and reaction, memory loss, mental retardation, drowsiness, or mental symptoms of paranoia, depression, anxiety, and in severe cases, myxedema-type epilepsy.

Anorexia, abdominal distension, and constipation are common, and in severe cases, paralytic intestinal obstruction may occur.

Loss of sexual desire, impotence in male patients, and menorrhagia or amenorrhea in female patients

It is more common in the elderly and has a high mortality rate. Clinical manifestations include lethargy, hypothermia, bradypnea, bradycardia, decreased blood pressure, limb muscle relaxation, and reflex weakening or disappearance. Involvement of the heart can cause pericardial effusion or heart failure. In severe cases, it may even lead to coma, shock, renal failure, and life-threatening conditions.