Symptoms include heat intolerance, excessive sweating, moist skin, low-grade fever, overeating and hunger, sharp weight loss, and fatigue.

High nervousness, talkativeness and restlessness, irritability, insomnia, inability to concentrate, memory loss, or even hallucinations, mania or schizophrenia, fine tremors of the arms, fingers and eyes closed, hyperreflexia of tendons, and occasionally manifested as Taciturn, depressed, indifferent

symptom

Increased appetite, loose stools, and increased frequency of defecation. Severe cases may include hepatomegaly, abnormal liver function, and occasionally jaundice. A few patients may experience loss of appetite, anorexia, nausea, and vomiting

It manifests as muscle weakness and muscle wasting, mainly thyrotoxic periodic paralysis. It is more common in adolescent males. The triggers include strenuous exercise, high carbohydrate diet, insulin injection, etc. The disease mainly affects the lower limbs. During the attack, blood potassium decreases, and the course of the disease is Self-limiting. Some patients develop hyperthyroid myopathy, presenting with progressive muscle weakness and muscle atrophy, which is more common in the proximal scapula and pelvic girdle muscles. Thick fingertips, myasthenia gravis and osteoporosis can be seen in a few cases

Reduced menstrual flow or amenorrhea in women, impotence in men, and occasional breast hyperplasia

The total number of white blood cells and granulocytes in peripheral blood may decrease, lymphocytes may increase, and hypochromic anemia may occur, which may be accompanied by thrombocytopenic purpura.

A small number of patients have typical symmetrical myxedema, local skin thickening and coarsening, which may be accompanied by secondary infection and pigmentation; proliferative subperiosteal osteitis, clubbing of fingers (toes)

Mild exophthalmos, the degree of exophthalmos generally does not exceed 18mm, and the normal degree does not exceed 16mm

Reduced blinking (Stellwag sign)

Upper eyelid contracture, wide palpebral fissure, and upper edge of cornea exposed when looking straight forward

When the eyes are looking downward, the upper eyelid cannot fall with the eyeball or falls behind the eyeball (von Graefe's sign)

The forehead skin should not wrinkle when looking upward (Joffroy's sign)

Poor eyeball convergence when looking at near objects (mobius sign)

It is rare, mostly occurs in adult patients, and has a poor prognosis. In addition to the more obvious eye signs mentioned above, it is often accompanied by swelling and hypertrophy of the eyelids and conjunctival congestion and edema. Swelling and hyperplasia of the soft tissue in the orbit and obvious lesions of the eye muscles make the eyeball significantly protruding (sometimes up to 30mm) and limited movement. Patients complained of foreign body sensation in the eyes, eye swelling and pain, photophobia, tearing, diplopia, strabismus, reduced visual field, and decreased vision. In severe cases, the ball is fixed and the left and right exophthalmos are unequal (difference >3mm). Exposure of the conjunctiva and cornea can easily cause bleeding, edema, and the formation of corneal ulcers, which may lead to blindness.