Characteristics of natural factors: BDNF and NGF are important but have limitations, refer to [5]

Biomimetic simulation nanocarrier system: using carriers to achieve slow release of neurotrophic factors, reference [6]

Genetic engineering technology: Constructing cells or vectors that express factors to improve the microenvironment, reference [7]

Case: Microfluidic chip technology is applied to neurotransmitter release research, etc., reference [8]

Importance of intercellular communication: important for neural tissue homeostasis, neuronal activity and regeneration, Reference [9]

bionic simulation method

Case: Self-assembly of phospholipids to prepare nanoparticles for the treatment of neurological diseases, reference [12]

Elements of the neuroregeneration microenvironment: suitable ingredients, concentrations and interactions, detrimental in aging, reference [13]

Build strategy

Case: Chitosan and hyaluronic acid hydrogel scaffold application, reference [16]

Technical complexity: multi-disciplinary, complex technical operations

Safety assessment: Materials and technologies have safety hazards

Individual differences: insufficient research, difficult to optimize strategies

Multidisciplinary integration: promoting innovative applications

Clinical needs: Neurodegenerative diseases are increasing, the needs are urgent and promising