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EdrawMindPharmacology——Rescue of organophosphate drug poisoning
MindMap Gallery Pharmacology——Rescue of organophosphate drug poisoning
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Pharmacology——Rescue of organophosphate drug poisoning
This is a mind map about the rescue of organophosphate drugs, the main contents include: 6. Common organophosphate esters, 5. Rescue of chronic poisoning, 4. AChE resurrection drugs, 3. Anticholinergic drugs, 2. Clearance of poisons, 1. Rescue 4 processes.
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Pharmacology——Rescue of organophosphate drug poisoning
- Reproductive system
This template shows the structure and function of the reproductive system in the form of a mind map. It introduces the various components of the internal and external genitals, and sorts out the knowledge clearly to help you become familiar with the key points of knowledge.
- Interpretation and summary of relationship field e-book
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- Accounting books and accounting records
This is a mind map about accounting books and accounting records. The main contents include: the focus of this chapter, reflecting the business results process of the enterprise, the loan and credit accounting method, and the original book of the person.
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- Outline
Rescue of organophosphate drug poisoning
1. Rescue 4 processes
"cut"
Quickly cut off the source of poison
"remove"
Quickly remove poisons
"untie"
Against M-like effects
AChE resurrection medicine
Symptom
Maintain airway patency and anti-shock
Artificial respiration, oxygen supply
Infusion, correct internal environmental disorders
2. Remove poisons
When absorbed by the skin
Lots of warm water and soap thoroughly Cleansing poisonous skin or head hair
It is not advisable to use hot water, Anti-vasodilation, add Fast poison absorption
When taken orally or food
Extract the contents of the stomach
2% sodium bicarbonate or 1% food Repeated and thorough gastric lavage with saline
Magnesium sulfate leads to diarrhea
Things to note
Enemies
Avoid using alkaline solution to rinse the stomach
Parathion
Avoid using potassium permanganate to wash the stomach
When absorbed by the eyes
Rinse for several minutes with 2% sodium bicarbonate or 0.9% brine
III. Anticholinergic drugs
atropine
Medicinal effect
M-like effects on ACh in vivo
No significant effect on the central nicotine receptor
Poor anti-correlation effects on central symptoms (such as convulsions, restlessness, etc.) caused by organophosphate poisoning
Things to note
Treatment measures that require early combined use of atropine and AChE resurrection drugs for patients with moderate or severe poisoning
veriquie
IV. AChE resurrection medicine
Iodine-phosphorus detergent
Also known as
Paim (PAM)
Features
The earliest AChE resurrection drug used
AChE resurrection drugs can also be directly combined with organophosphate esters to form Toxic phosphorylation is eliminated from urine
Low water solubility, unstable solution, long-term storage can release iodine
Chlorolysis Phosphorus
Features
AChE resurrection drug that is commonly used in clinical practice
AChE resurrection drugs can also be directly combined with organophosphate esters to form Toxic phosphorylation is eliminated from urine
Good water solubility, stable solution properties
Clinical application
Mainly used in the treatment of moderate and severe organophosphate poisoning
Ineffective for "aging" phosphorylated AChE, so it needs to be used early
No direct countermeasures on ACh accumulated in the body
Therefore, it is necessary to use it in conjunction with atropine to control symptoms and improve therapeutic efficacy
Can quickly control skeletal muscle tremor
It also has certain effects on the symptoms of poisoning in the central nervous system
However, the recovery of autonomic nervous system function is poor
Features
Parathion, malathion and parathion are more effective
Poor therapeutic effect on DDT and Hundred Worms
Ineffective against Leguo (the phosphorylated AChE formed during Leguo is almost irreversible)
5. Rescue of chronic poisoning
For chronic organophosphate poisoning, there is currently a lack of effective treatment methods.
Both atropine and AChE resurrection drugs are not effective
When AChE activity decreases below 50% when a production worker or long-term contact is found
Before the symptoms appear, you should completely leave the scene to avoid deepening the poisoning
6. Common organophosphate esters
Internal phosphorus absorption, parathion
Leguo, DDT, HGT, Malathion
Sharin, Tabeng, Soman
Ethion, isofluorophosphorus