MindMap Gallery Chapter 24 Peptic ulcer
Internal Medicine Chapter 3 Digestive System Diseases Peptic ulcer PU, including gastric ulcer GU and duodenal ulcer DU. GU mainly means that defense and repair factors are weakened, while DU mainly means that invasion factors are enhanced.
Edited at 2023-10-29 23:26:39Microbiologie médicale, infections bactériennes et immunité résume et organise les points de connaissances pour aider les apprenants à comprendre et à se souvenir. Étudiez plus efficacement !
Medical Microbiology Bacterial Infection and Immunity summarizes and organizes knowledge points to help learners understand and remember. Study more efficiently!
The kinetic theory of gases reveals the microscopic nature of macroscopic thermal phenomena and laws of gases by finding the relationship between macroscopic quantities and microscopic quantities. From the perspective of molecular motion, statistical methods are used to study the macroscopic properties and change patterns of thermal motion of gas molecules.
Microbiologie médicale, infections bactériennes et immunité résume et organise les points de connaissances pour aider les apprenants à comprendre et à se souvenir. Étudiez plus efficacement !
Medical Microbiology Bacterial Infection and Immunity summarizes and organizes knowledge points to help learners understand and remember. Study more efficiently!
The kinetic theory of gases reveals the microscopic nature of macroscopic thermal phenomena and laws of gases by finding the relationship between macroscopic quantities and microscopic quantities. From the perspective of molecular motion, statistical methods are used to study the macroscopic properties and change patterns of thermal motion of gas molecules.
peptic ulcer PU
Including gastric ulcer GU and duodenal ulcer DU. GU mainly means that defense and repair factors are weakened, while DU mainly means that invasion factors are enhanced.
Etiology and pathogenesis
HP
Considered an important cause of PU
Non-steroidal anti-inflammatory drugs NSAIDs
Another common cause of PU
Stomach acid and pepsin
other
smoking
genetics
Acute stress can cause stress ulcers
Abnormal movement of stomach and duodenum
clinical manifestations
Symptoms: Upper abdominal pain is the most prominent symptom
pain characteristics
Chronic
cyclical
rhythmicity
DU often suffers from pain when hungry, which is relieved after eating. Some DU patients have night pain and are often awakened by pain.
The rhythm of GU pain is irregular and often occurs within 1 hour after a meal and disappears before the next meal.
Nature and location of pain
Pain can be dull, burning, distending, or hunger pangs
GU pain is found in the middle and upper abdomen or on the left side, while DU pain is mostly located on the right side of the middle and upper abdomen.
Sudden pain or sudden intensification of pain, severe pain, rapidly spreading from the upper abdomen to the entire abdomen, attention should be paid to the occurrence of acute free perforation
If the pain is severe and radiates to the back, and cannot be relieved by antacid treatment, chronic penetrating ulcer of the posterior wall should be considered.
special type
compound ulcer
DU and GU occur at the same time, DU often appears before GU, and the incidence of pyloric obstruction is higher.
retrobulbar ulcer
Night pain and radiating pain to the back are more common, and are easily complicated by bleeding
huge ulcer
peptic ulcer in the elderly
Clinical manifestations are often atypical
asymptomatic ulcer
About 15% of patients with peptic ulcer have no obvious symptoms, and complications such as bleeding and perforation are the first manifestations.
complication
Bleeding
It is the most common complication of peptic ulcer, and ulcer is the most common cause of gastrointestinal bleeding.
perforation
Free perforation can cause acute diffuse peritonitis
Penetrating ulcer, the organ most commonly penetrated is the pancreas
subacute perforation
fistula
Typical clinical manifestations of acute perforation
Sudden severe pain in the upper abdomen, which quickly spreads to the entire abdomen, often accompanied by nausea, vomiting, and fever. The patient is often restless, pale, clammy limbs, thin and rapid pulse, plate-shaped abdomen, abdominal tenderness, rebound tenderness, and liver disease. The boundaries of dullness are reduced or disappeared, and bowel sounds are weakened or disappeared.
Abdominal X-ray examination reveals free air shadow under the diaphragm, which is an important basis for diagnosing perforation.
Pyloric obstruction
It is mostly caused by congestion, edema and pyloric spasm of the tissue around the ulcer. It is relieved as the inflammation improves and is called temporary and functional obstruction.
Chronic obstruction is persistent primarily due to scar shrinkage
Pain worsens after meals, accompanied by nausea and vomiting, which can lead to dehydration and hypokalemia and hypochloremic alkalosis.
cancer
A small number of GU can become cancerous, but DU does not.
I have a long-term history of chronic GU. I am 45 years old. The ulcer is stubborn and does not heal. I should be alert to cancer.
Auxiliary inspection
Gastroscopy
Is the preferred method for diagnosing peptic ulcer
X-ray barium meal examination
HP test
Gastric juice analysis and serum gastrin determination
Differential diagnosis
chronic gastritis
It often presents with upper abdominal fullness and belching, which is aggravated after eating, and does not have the characteristics of rhythmic pain of peptic ulcer. However, PU is often complicated by chronic gastritis. When identification is difficult, gastroscopy can be used to confirm the diagnosis.
functional dyspepsia
Symptoms such as upper abdominal distension and pain, acid reflux, belching, burning sensation, nausea, vomiting, and loss of appetite are common, and they resemble atypical ulcers. The identification relies on gastroscopy and X-ray barium meal.
Cholecystitis and gallstones
Right upper abdominal pain radiating to the right shoulder and back may occur after eating greasy food, which may be accompanied by fever, jaundice, and a positive Murphy sign. Abdominal B-ultrasound, MRCP, ERCP assist in diagnosis
Gastric cancer gastroscopy features
Ulcers are generally larger and irregular in shape
The bottom is uneven and the moss is dirty
The edge of the ulcer is nodular and raised
middle section of surrounding wrinkled wall
Stomach wall stiffness and weakened peristalsis
gastrinoma
treat
Principle: Eliminate the cause, relieve symptoms, promote healing, prevent recurrence and prevent complications
General treatment
medical treatement
Treatment to eradicate H pylori
Treatment options to eradicate H pylori
A treatment plan that combines gastric acid secretion inhibitors, antibiotics, or synergistic colloidal bismuth. separable There are two types of solutions: proton pump inhibitor (PPI)-based and colloidal bismuth agent-based. For those who fail the first treatment, PPI, Quadruple therapy with colloidal bismuth combined with two antibacterial drugs (clarithromycin, amoxicillin, and metronidazole)
Is it necessary to continue anti-ulcer treatment after eradication of Hp?
When the treatment plan is highly effective and the ulcer area is not very large, a single anti-Hp treatment can cure active ulcers in 1 to 2 weeks. heal. If the Hp eradication program is less effective, the ulcer area is larger, and the patient’s symptoms are not relieved at the end of anti-Hp treatment or have a recent history of complications such as bleeding, you should consider continuing treatment with gastric acid secretion-inhibiting drugs after the anti-Hp treatment is completed. 2 to 4 weeks.
Review after anti-Hp treatment
Inhibit gastric acid secretion
H2 receptor antagonist H2RA
Cimetidine 400mg, twice daily
Ranitidine 150mg, twice daily
Proton pump inhibitor PPI
Omeprazole 20mg/d
Drugs to protect gastric mucosa
Antacids: weakly alkaline, can neutralize gastric acid and quickly relieve pain
Sucralfate 4 times a day, 1g each time, taken orally 1 hour before meals and before going to bed, 4-6 weeks is a course of treatment
Bismuth agent: White bismuth oxide precipitate is formed under the action of gastric acid, forming a bismuth peptide complex protective film on the ulcer surface, inhibiting pepsin activity, and has a strong anti-Hp effect
4 times a day, 0.3g each time (containing 110mg bismuth), taken before three meals and 2 hours after dinner.
Prostaglandin E: Misoprostol inhibits gastric acid secretion, increases mucus and bicarbonate secretion in the gastroduodenal mucosa, and increases mucosal blood flow.
Treatment of Ulcers with NSAIDs
Treatment of complications
Surgical treatment indications for surgery
① Massive bleeding that fails medical treatment
②Acute perforation
③Cicatricial pyloric obstruction
gastric ulcer cancer
Intractable ulcers that fail to respond to strict medical treatment