According to the condition, blood picture, bone marrow picture and prognosis

According to the cause

1) Viral infection, especially hepatitis virus, parvovirus B19, etc.

2) Chemical factors, especially chloramphenicol antibiotics, sulfa drugs, etc.

3) Long-term exposure to X-rays, radium and radionuclides can affect DNA replication, inhibit cell mitosis, interfere with bone marrow cell production, and lead to a reduction in the number of hematopoietic stem cells.

1) Hematopoietic stem and progenitor cell defects (seed theory)

2) Abnormal hematopoietic microenvironment (soil theory)

3) Immunity abnormality (bug theory)

1) Anemia: mostly progressively worsening

2) Infection: Most patients have fever, and some patients suffer from uncontrollable high fever from onset to death, often accompanied by sepsis.

3) Bleeding: Bleeding occurs in all cases. In addition to skin and mucous membranes, there is often visceral bleeding, and even intracranial bleeding can lead to death.

1) Anemia: milder than SAA

2) Infection: Mild and easy to control

3) Bleeding: Mild, visceral bleeding is rare

1) Severe pancytopenia

2) The absolute value of reticulocytes decreases

3) Relative increase in lymphocytes

1) Low hematopoietic function in at least one part

2) Reduction of megakaryocytes

1) Decreased CD4 cell:CD8 cell ratio

2) Increased ratio of Th1:Th2 type cells, etc.

IAA diagnostic criteria

Diagnostic criteria for II AA classification

I Paroxysmal nocturnal hemoglobinuria (PNH)

II Myelodysplastic Syndrome (MDS)

III Autoantibody-Mediated Pancytopenia

IV acute leukemia (AL)

V Acute hematopoietic arrest

VI Others: Reactive hemophagocytic syndrome

A protective measures

B Symptomatic treatment

A Immunosuppressive treatment

B Treatment to promote hematopoiesis

C Hematopoietic stem cell transplantation