Wondershare EdrawMind
EdrawMindCause of Cell Injury Mind Map
MindMap Gallery Cause of Cell Injury Mind Map
- 324
- 2
Cause of Cell Injury Mind Map
Cell injury can occur when cells are subjected to any kind of harmful stimulus. Factors that can lead to cell injury include physical, chemical, and biological agents, as well as nutritional deficiencies or excesses. These agents can cause oxidative stress, inflammation, apoptosis (cell death), or necrosis (tissue death). It is mandatory to identify the causes of cell injury in order to take measures to reduce further damage. A cell injury mind map is a visual representation of the effects and processes that occur when cells are exposed to physical or metabolic stress. It includes diagrams displaying the responses from cells on a cellular level and can be used to study the mechanisms of cell injury, inflammation, and death. The mind map serves as an educational tool to help students better understand how their bodies respond to these external stimuli. With the help of EdrawMind, you can create similar mind maps illustrating different causes of cell injury.
Edited at 2023-01-29 10:30:42- Healing and repair-3
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Healing and repair-2
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Healing and repair-1
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Cause of Cell Injury Mind Map
- Healing and repair-3
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Healing and repair-2
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Healing and repair-1
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Recommended to you
- Outline
cell injurey
Injury
Reversible
Pathogenesis
Mitochondrial oxidative phosphorylation is disrupted first SO RED ATP SO
RED Na/K ATPase SO INCintracellular Na SO cell swelling
RED ATP-dependent Ca pumps SO INC cytoplasmic [Ca]
Anaerobic respiration SO RED glycogen
Lactic acid accumulation SO RED pH
Detachment of ribosomes from RER SO RED protein synthesis
End result is cytoskeletal disruption with loss of microvilli, bleb formation, etc
Morphology
Light microscopic changes
Cell swelling (i.e., hydropic change)
Fatty change
Ultrastructural changes
Alterations of cell membrane
Swelling of and small amorphous deposits in mitochondria
Swelling of RER and detachment of ribosomes
LEADS TO
Recovery
Irreversible
Pathogenesis
Mitochondrial swelling with formation of large amorphous densities in matrix
Lysosomal membrane damage leakage of proteolytic enzymes into cytoplasm
Membrane damage and loss of calcium homeostasis are most crucial
Too much cytoplasmic calcium
Denatures proteins
Poisons mitochondria
Inhibits cellular enzymes
Morphology
Light microscopic changes
Increased cytoplasmic eosinophilia (loss of RNA, which is more basophilic)
Cytoplasmic vacuolization
Nuclear chromatin clumping
Ultrastructural changes
Breaks in cellular and organellar membranes
Larger amorphous densities in mitochondria
Nuclear changes
Pyknosis
Nuclear shrinkage and increased basophilia
Karyorrhexis
Fragmentation of the pyknotic nucleus
Karyolysis
Fading of basophilia of chromatin
LEADS TO
Cell death
Necrosis
Apoptosis
causes
Hypoxia and ischemia
Pathogeneses
Hypoxia ≠ Ischemia
Hypoxemia: reduce of oxygen carrying capacity
Ischemia: reduce blood supply
SO rapidlyRED oxygen and glycogen + metabolites accumulate and are not carried away by circulation (more rapid and severe acidosis)
Lead to faliure of many energy dependant metabolic pathways SO failure RED of ATP SO death
Consecunses
Block in ventilation (e.g., foreign body)
Block in diffusion of oxygen (e.g., pneumonia, pulmonary edema)
Block in perfusion (e.g., pulmonary embolus)
Decreased cardiac output
Decreased oxygen carrying capacity (e.g., anemia)
Ischemia (e.g., blockage of blood flow)
Free radical damage
Oxidative Stress
Free radicals have an unpaired electron in their outer orbit and it cause cellular chain reactions generated by
Absorption of radiant energy
Oxidation of endogenous constituents
Oxidation of exogenous compounds
Examples of Free Radical Injury
Chemical (e.g., acetaminophen)
Inflammation / Microbial killing
Irradiation (e.g., UV rays skin cancer)
Oxygen (e.g., exposure to very high oxygen tension on ventilator)
Age-related changes
Mechanism of Free Radical Injury
Lipid peroxidation SO damage to phospholipids (cellular and organellar membranes) and proteins
Oxidized phospholipids and proteins are not readily broken down SO accumulate and aggregate
Protein cross-linking and fragmentation due to oxidative modification of amino acids and proteins
DNA damage due to reactions of free radicals with thymine
Chemicals, drugs, toxins (e.g., acids, bases, organo-phosphates)
Environmental chemicals and substances produced by infectious pathogens SO injury SO death
Direct-acting toxins e.g., HgCl2
Latent e.g., CCl4
Infections
Aging
Endoplasmic Reticulum Stress
INC Production of misfolded proteins + RED elimination of them can stress compensatory pathways in the ER SO injury SO death
Immunologic reactions
Genetic abnormalities (e.g., storage diseases, enzyme deficiencies)
Nutritional imbalance (e.g., protein or calorie malnutrition)
Physical agents
CELL INJURY HAPPENS ONLY IN THE CELL CLOUDN'T ADAP
Ischemia Reperfusion Injury
Paradoxically increase cell injury
Inflammation that is induced by ischemic injury may increase with reperfusion
INC ROS ( by injured cells and infiltrating leukocytes)