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Healing and repair-1
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Edited at 2023-02-16 01:39:06- Healing and repair-3
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Healing and repair-2
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Healing and repair-1
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
Healing and repair-1
- Healing and repair-3
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Healing and repair-2
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
- Healing and repair-1
Healing and repair are essential processes that occur in various aspects of life, including physical, emotional, and societal realms. This mind map aims to explore the concept of healing and repair. Whether it is recovering from physical injuries, emotional trauma, or restoring broken relationships, healing and repair play a crucial role in promoting well-being and growth. By following this mind map, individuals can gain insights into the different dimensions of healing and repair and discover effective methods to facilitate their own personal growth and contribute to the healing of others and the world around them. Let's embark on this journey and explore the transformative power of healing and repair.
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- Outline
Healing 1
REGENERATION
What is it
Growth of new cells to replace lost ones (complete resolution) and has the following features
Restoring the lost structures, and function
Is dependent on the ability of the tissue to divide
It should be differentiated from “compensatory” growth
HEALING
HEALING
Reparative tissue response to large damage, or necrosis by inflammation (healing by fibrosis) through two steps
Granulation and fibrosis
Organizing
Features
Associated with an inflammatory process, and necrosis
Many diseases are a result of “healing” such as atherosclerosis is considered a healed endothelial injury
Often ends with a scar (fibrosis)
Requires a connective tissue “scaffold”
Fibrosis occurs in proportion to the damage of the ECM
Repair by Connective Tissue (Fibrosis)
it is a replacement of damaged tissues by fibrous connective tissues
which eventually results in the formation of a scar
This type of repair occurs when injuries of permanent cells or when the injury results in extensive damage to the stromal framework and supporting connective tissues
This type of repair occurs when injuries of permanent cells or when the injury results in extensive damage to the stromal framework and supporting connective tissues
This type of repair occurs when injuries of permanent cells or when the injury results in extensive damage to the stromal framework and supporting connective tissues
Granulation tissue
It begins as early, by three to five days, a specialized type of tissue appears composed of fibroblasts and newly formed blood vessels
The process resulting in the development of these newly formed blood vessels is called angiogenesis or neovascularization
Stem cell pathways
STEM cells
Baseline cell population
Proliferation
Differenitiarion
Cell death ( apoptosis )
Cell’s ability to renew itself
Cells of the body are divided into three groups
Based on their regenerative capabilities
Labile Cells
These cells are continuously in a proliferative state, to replace dead cells that are being destroyed
example, skin, gastrointestinal tract, genitourinary tract, and hematopoietic cells. These cells will be healed by regeneration if damaged.
healed by regeneration if damaged
Stable Cells
examples , liver, proximal tubules of the kidney, and endocrine glands, endothelium, smooth muscle, and mesenchymal cells such as fibroblasts, osteoblasts, & chondroblasts
Stable cells are cells that will be divided only when in need,
They spend most of the time in the quiescent (G0 phase) of the cell cycle but can be stimulated to enter the cell cycle when needed.
healed by regeneration
Permanent Cells
These cells are incapable of division; however, some portions of these cells may be restored as in CNS neurons, the cells themselves do not regenerate,
Example, skeletal and cardiac muscle., Healing and repair will be by fibrosis
repair by fibrous becomes more likely
why extensive damage healed by fibrosis
scaffolding provided by stroma and basement membranes is so important to structure in the healing by regeneration. However, if these structures are also damaged, then repair by fibrous becomes more likely.
CELL CYCLE
G0: Quiescent phase (not a very long or dominant phase)
G1: PRE-synthetic gap, not quiescent GROWTH
S: DNA synthesis phases
Cells which have continuous “turnover” have longer, or larger S-phases,
S-phase of TUMOR CELLS can be prognostic
G2: PRE-mitotic gap
M : (Mitotic:, division of the cell, controlled by Cytokinesis)
angiogenesis
The process of angiogenesis is found in healing and in tumors formation.
enzymatic degradation of the basement membrane of the parent vessel,
migration of endothelial cells toward the angiogenic stimulus, proliferation of endothelial cells,
maturation of endothelial cells
Organize into capillary tubes.
These newly formed vessels have leaky junctions, thus granulation tissue tends to be edematous.
Granulation tissue has considerable numbers of macrophages, their main purpose is to eliminate injurious agents.
Macrophages also remove extracellular debris, a process by which the excess granulation tissue is removed.
In addition, granulation tissue may have varying numbers of neutrophils, lymphocytes, and eosinophils
Mechanisms Involved in Repair
The mechanisms regulating repairs include:
Growth factors production, and growth inhibitors
Cell to cell and cell to matrix interactions. Contact inhibition
Extracellular matrix synthesis and collagenization