1) Bacterial infection

2) Viral infection

3) Rickettsia infection

4) Other infections

1) Microthrombosis is the basic and specific pathological change of DIC

2) Mainly fibrin thrombus and fibrin-platelet thrombus

1) Hypercoagulable state: an early change in DIC

2) Consumptive hypocoagulable state: bleeding tendency

3) Secondary hyperfibrinolytic state: often occurs in the late stage of DIC

Microcirculation disorders are caused by factors such as capillary microthrombosis, reduced blood volume, vasomotor dysfunction, and impaired cardiac function.

1) Characterized by spontaneous and multiple bleeding

2) The site can be all over the body, and in severe cases, intracranial hemorrhage may occur.

1) A transient or sustained drop in blood pressure

2) Early onset of kidney, lung, brain and other organ dysfunction

3) Symptoms include clammy limbs, oliguria, dyspnea, cyanosis and mental changes, etc.

presenting as progressive anemia

I Clinical manifestations

II Experimental Check Indicators

1) Control infection, correct hypoxia, ischemia and acidosis, etc.

2) It is the most critical and fundamental treatment measure to terminate the pathological process of DIC.

1) Anticoagulation therapy is an important measure to terminate the pathological process of DIC, reduce organ damage, and reestablish the coagulation-anticoagulation balance.

2) The commonly used anticoagulant drugs in clinical practice are heparin: unfractionated heparin and low molecular weight heparin

3) Contraindications to anticoagulation therapy

1) Fresh frozen plasma and other blood products

2) Platelet suspension

3) Fibrinogen

4) F VIII and prothrombin complex