Hemorrhage, shock, organ dysfunction, microangiopathic hemolytic anemia, etc.

31-43% infectious diseases (bacterial infection, sepsis, viral myocarditis, etc.)

24-34% neoplastic diseases (pancreatic cancer, colon cancer, leukemia, cervical cancer, etc.)

4-12% Obstetric and gynecological diseases (miscarriage, amniotic fluid embolism, stillbirth, etc.)

1-5% trauma and surgery (severe soft tissue trauma, extensive burns, organ transplantation, etc.)

Tissue factor is released, the exogenous coagulation system is activated, and the coagulation process is initiated.

Damage to vascular endothelial cells, disorders of coagulation and anticoagulation regulation

Massive destruction of blood cells and activation of platelets

Procoagulant substances enter the blood

Closely related to coagulation (the main anticoagulant substances are synthesized in the liver, and coagulation factors are also inactivated in the liver)

Starting from the third week of pregnancy, platelets and coagulation factors increase in the blood of pregnant women.

Blood clotting substances are consumed and reduced

fibrinolytic system activation

Fibrin(ogen) degradation product formation

Microvascular damage

A large number of microthrombi cause microcirculation disorders and lead to ischemic organ dysfunction.

Involvement of the adrenal glands causes hemorrhagic necrosis of the adrenal cortex, leading to Wolff syndrome.

Involvement of the pituitary gland leads to necrosis, leading to Shearen syndrome.

DIC and shock are cause and effect of each other, forming a vicious cycle. (DIC reduces effective blood volume and causes shock)

Patients with DIC develop microangiopathic hemolytic anemia.

mechanism